DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20214341

A retrospective analysis of mid trimester termination of pregnancies for fetal congenital malformations at tertiary care hospital

Geethalakshmi Suriyanarayanan, Vijayalakshmi Kandasamy, Anuradha Coimbatore Ramachandran

Abstract


Background: This study was conducted to analyse the spectrum of fetal anomalies as a cause of pregnancy termination in a tertiary care hospital.

Methods: This retrospective study includes antenatal women with fetal anomalies diagnosed by an ultrasound (USG) and admitted in Chettinad Hospital and Research Institute, Kelambakkam from January 2018 to January 2020 for termination of pregnancy. Data was collected from hospital records and analysed.

Results: Gestational age of women with fetal congenital anomalies ranged from 13 to 21 weeks. Pregnancy termination, was performed between 17-19 weeks of gestation in 41% of patients, between 13-15 weeks and 19-21 weeks in 23% of women respectively. Congenital fetal anomalies resulting in termination of pregnancy were CNS, musculoskeletal, cardiovascular, renal and multiple anomalies. CNS abnormalities was a major cause of termination of pregnancy which includes meningomyelocele, spina bifida, acrania, anencephaly.

Conclusions: In our study conducted at our tertiary care center, CNS abnormalities were the major cause of mid trimester termination of pregnancies, followed by musculoskeletal abnormalities being second most common cause.


Keywords


Congenital anomalies, Fetal, Pregnancy termination, Second trimester, Ultrasound

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References


ACOG practice bulletin number 77: screening for fetal chromosomal abnormalities. Obstet Gynecol. 2007;109:217-27.

Rosano A. Infant mortality and congenital anomalies from 1950 to 1994: an international perspective. J Epidemiol Community Health. 2000;54:660-6.

Women’s NCCf, Health Cs. Antenatal care: routine care for the healthy pregnant woman. RCOG press; 2008.

Anderson N, Boswell O, Duff G. Prenatal sonography for the detection of fetal anomalies: results of a prospective study and comparison with prior series. AJR Am J Roentgenol. 1995;165:943-50.

Napolitano R, Thilaganathan B. Late termination of pregnancy and fetal reduction for fetal anomaly. Best Pract Res Clin Obstet Gynaecol. 2010;24(4):529-37.

Liu S. Relationship of prenatal diagnosis and pregnancy termination to overall infant mortality in Canada. JAMA. 2002;287:1561-7.

Agarwal SS, Singh U, Singh PS, Singh SS, Das V, Sharma A, et al. Prevalence and spectrum of congenital malformations in a prospective study at a teaching hospital. Indian J Med Res. 1991;94:413-9.

Taksande A, Vilhekar K, Chaturvedi P, Jain M. Congenital malformations at birth in central India: a rural medical college hospital based data. Indian J Hum Genet. 2010;16:159.

Singh A, Gupta RK. Pattern of congenital anomalies in new-born: a hospital based prospective study. JK Sci. 2009;1:34-6.