Published: 2021-09-27

Development and management of ovarian hyperstimulation syndrome in spontaneous singleton pregnancy

Sercan Kantarcı, Yaşam Kemal Akpak, Betül Öztürk, Serkan Oral, Atakan Emre, Alper İleri, Adnan Budak, Gökhan Tosun, Hamdi İnan, Mehmet Özeren


Ovarian hyperstimulation syndrome (OHSS) is one of the most life-threatening complications of ovulation induction. However, rarely, OHSS can develop spontaneously during pregnancy without induction of ovulation. It has been shown in the literature that some diseases such as polycystic ovary syndrome (PCOS), hypothyroidism, and pituitary adenoma may accompany spontaneous OHSS. Spontaneous OHSS should be included in the differential diagnosis in first-trimester pregnancies with nausea, vomiting, and acute abdomen. The focus should be on preventing possible complications and initiating early treatment immediately after diagnosis.


Spontaneous ovarian hyperstimulation syndrome, Ovarian torsion, Pregnancy first trimester complications, Ovarian cysts, Ovulation induction

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