DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20213867

Development and management of ovarian hyperstimulation syndrome in spontaneous singleton pregnancy

Sercan Kantarcı, Yaşam Kemal Akpak, Betül Öztürk, Serkan Oral, Atakan Emre, Alper İleri, Adnan Budak, Gökhan Tosun, Hamdi İnan, Mehmet Özeren

Abstract


Ovarian hyperstimulation syndrome (OHSS) is one of the most life-threatening complications of ovulation induction. However, rarely, OHSS can develop spontaneously during pregnancy without induction of ovulation. It has been shown in the literature that some diseases such as polycystic ovary syndrome (PCOS), hypothyroidism, and pituitary adenoma may accompany spontaneous OHSS. Spontaneous OHSS should be included in the differential diagnosis in first-trimester pregnancies with nausea, vomiting, and acute abdomen. The focus should be on preventing possible complications and initiating early treatment immediately after diagnosis.


Keywords


Spontaneous ovarian hyperstimulation syndrome, Ovarian torsion, Pregnancy first trimester complications, Ovarian cysts, Ovulation induction

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References


Ezra Y. Modern trends. Fertil Steril. 1994;61(3):411-22.

Ahmed Kamel RM. Spontaneous ovarian hyperstimulation syndrome in a naturally conceived singleton pregnancy. Fertil Steril. 2010;94(1):351.e1-4.

Mittal K, Koticha R, Dey AK Anandpara K, Agrawal R, Sarvothaman MP, et al. Radiological illustration of spontaneous ovarian hyperstimulation syndrome. Polish J Radiol. 2015;80(1):217-27.

Di Carlo C, Savoia F, Fabozzi A, Gargano V, Nappi C. Case Report: A case of ovarian torsion in a patient carrier of a FSH receptor gene mutation previously affected by spontaneous ovarian hyperstimulation syndrome. Gynecol Endocrinol. 2014;3590:1-4.

Borna S, Nasery A. Spontaneous ovarian hyperstimulation in a pregnant woman with hypothyroidism. Fertil Steril. 2007;88(3):705.e1-3.

Di Carlo C, Savoia F, Gargano V, Sparice S, Bifulco G, Nappi C. Successful pregnancy complicated by spontaneous, familial, recurrent ovarian hyperstimulation syndrome: Report of two cases. Gynecol Endocrinol. 2013;29(10):897-900.

Oral S, Akpak YK, Karaca N, Savan K. The Importance of Prolactin Levels in Patients Treated with Cabergoline for the Prevention of OHSS: Is Cabergoline Really Effective in Patients with High Risk of OHSS? Open J Obstet Gynecol. 2015;05(06):344-9.

Binder H, Dittrich R, Einhaus F, Krieg J, Müller A, Strauss R, et al. Update on ovarian hyperstimulation syndrome: Part 1--Incidence and pathogenesis. Int J Fertil Womens Med. 2007;52(1):11-26.

Cabar FR. Ovarian hyperstimulation syndrome in a spontaneous singleton pregnancy. Einstein (Sao Paulo). 2016;14(2):231-4.

De Leener A, Montanelli L, Van Durme J, Chae H, Smits G, Vassart G, et al. Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology. J Clin Endocrinol Metab. 2006;91(2):555-62.

Zalel Y, Orvieto R, Ben-Rafael Z, Homburg R, Fisher O, Insler V. Recurrent spontaneous ovarian hyperstimulation syndrome associated with polycystic ovary syndrome. Gynecol Endocrinol. 1995;9(4):313-5.

Krishnakumar S, Kuris S, Kaveri R, Joshi A, Krishnakumar R. Spontaneous OHSS in a Young Adolescent: A Diagnostic Dilemma. J Obstet Gynecol India. 2020;70(3):237-9.

Haimov-Kochman R, Yanai N, Yagel S, Amsalem H, Lavy Y, Hurwitz A. Spontaneous ovarian hyperstimulation syndrome and hyperreactio luteinalis are entities in continuum. Ultrasound Obstet Gynecol. 2004;24(6):675-8.

Rackow BW, Patrizio P. Successful pregnancy complicated by early and late adnexal torsion after in vitro fertilization. Fertil Steril. 2007;87(3):697.e9-12.

Practice T, Medicine R. Ovarian hyperstimulation syndrome. Fertil Steril. 2008;90(5 Suppl):188-93.