Published: 2021-10-27

Impact of COVID 19 in antenatal patient with gestational diabetes mellitus and vice a versa: a retrospective study

Sapna Singh, Preeti Tyagi, Rashmi Gupta, Deepak Anand, Sandhya Yadav


Background: The objective of this study is to compare the incidence, severity and feto-maternal outcome of antenatal Coronavirus disease 2019 (COVID-19) positive patients with GDM vs non GDM patients.

Methods: This is a retrospective observational study. The study was carried out in department of Obstetrics and Gynecology, GSVM Medical College, Kanpur from March 2020 to December 2020. All the antenatal women with COVID 19 positive status who were admitted during this period were enrolled in the study. Analysis were made on the basis of observation regarding the severity of symptoms COVID 19 disease, oxygen requirements, mode of delivery and neonatal outcome in GDM vs non GDM COVID positive antenatal patient.

Results: A total of 421 COVID positive antenatal patients were enrolled of which 21 patients were having GDM and 400 were non GDM. Of these 21 patients, 14 (66.7%) were diagnosed with GDM after admission while 7 patients i.e., 33.3% were already diagnosed GDM before admission in current pregnancy. Of these 21 (42.9%) antenatal COVID pt with GDM majority shows mild symptoms of COVID 19, however the severity of fever, myalgia and cough was increased in GDM compared to Non GDM Group. While in non GDM Group, majority of patients were asymptomatic (44.3%) and severity was also less.

Conclusions: It is also evident that patients with GDM had longer duration of hospital stay, higher incidence of caesarean delivery and oxygen requirements.


COVID 19, Antenatal, GDM, Severity, Vertical transmission

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Naz MS, Shehla B, Farrukh N, Yasir M, Raheel S, Rizwana C et al. Guidelines for management of hyperglycemia in pregnancy (HIP). 2021;12(1):83-98.

Guariguata L, Linnenkamp U, Beagley J, Whiting DR, Cho NH. Global estimates of the prevalence of hyperglycemia in pregnancy .Diabetes Res Clinical practical. 2014;103(2):176-85.

McIntyre HD, Moses RG. The diagnosis and management of gestational diabetes mellitus in the context of the COVID-19 pandemic. Diabetes care. 2020;43(7)1433-4.

Seshiah V, Balaji V, Balaji S, Sekar A, Sanjeevi CB, Green A. One step screening procedure for screening and diagnosis of gestational diabetes mellitus. J Obstet Gynecol India. 2005;55(6):525-29.

Clinical management protocol: covid19 Version 4, 27.06.20 Government of India, ministry of health and family welfare.

Poon LC, Yang H, Kapur A. Global interim guidance on coronavirus disease 2019 (COVID-19) during pregnancy and puerperium from FIGO and alied partners: information for healthcare professionals.

Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. The Lancet. 2020;6736(20):1-7.

Kotlyar AM, Grechukhina O, Chen A, Popkhadze S, Grimshaw A, Tal O et al. Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis.2qq Am J Obstet Gynecol. 2021;224(1):35-53.