DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20213507

Advanced ovarian malignancy in pregnancy mimicking ovarian hyperstimulation syndrome: a case report

Mythili Kundur, Anupama Rajanbabu, Vinita Murali, Pavithran Keechilatt

Abstract


Advanced ovarian malignancy is a rare occurrence in pregnancy. Here we report a case of primary infertility presenting in early pregnancy following invitro fertilization with features of Ovarian hyperstimulation syndrome unresponsive to treatment. Further evaluation revealed advanced ovarian malignancy. She was treated with chemotherapy followed by staging surgery at the time of elective cesarean at 35 weeks gestation. This case outlines the difficulties in diagnosis of ovarian cancer during pregnancy.


Keywords


Ovarian cancer, Epithelial ovarian cancer, OHSS, Diagnosis, IVF

Full Text:

PDF

References


Franciszek, Dłuski D, Mierzyński R, Poniedziałek-Czajkowska E, Leszczyńska-Gorzelak B. Ovarian Cancer and Pregnancy-A Current Problem in Perinatal Medicine: A Comprehensive Review. Cancers (Basel). 2020;12(12):3795.

El Tokhy O, Kopeika J, El-Toukhy T. An update on the prevention of ovarian hyperstimulation syndrome. Womens Health (Lond). 2016;12(5):496-503.

Kroener L, Dumesic D, Al-Safi Z. Use of fertility medications and cancer risk: a review and update. Curr Opin Obstet Gynecol. 2017;29(4):195-201.

Ben-Hur H, Dgani R, Lancet M, Katz Z, Nissim F, Rosenman D. Ovarian carcinoma masquerading as ovarian hyperstimulation syndrome. Acta Obstet Gynecol Scand. 1986;65(7):813-4.

Amampai R, Suprasert P. Cancer Antigen 125 during Pregnancy in Women without Ovarian Tumor Is Not Often Rising. Obstet Gynecol Int. 2018;2018:8141583.

Han SN, Lotgerink A, Gziri MM. Physiologic variations of serum tumor markers in gynecological malignancies during pregnancy: a systematic review. BMC Med. 2012;10:86.

Martone S, Troìa L, Luisi S. Adnexal masses during pregnancy: management for a better approach. Gynecol Surg. 2021;18:3.

T RK, Korenaga KS. Tewari, Gynecologic cancer in pregnancy, Gynecologic Oncology. 2020;127(3):799-809.

Amant F, Berveiller P, Boere IA, Cardonic E. Gynecologic cancers in pregnancy: Guidelines based on a third international consensus meeting, Annals of Oncology. 2019;30(3):1601-12.