DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20213488

Spontaneous pregnancy in a patient with premature ovarian insufficiency after a failed attempt of ovulation induction

Nasuha Yaacob, Fadzlin M. Adzlan, Siti Nabillah Ab Rahman

Abstract


Premature ovarian insufficiency (POI) is defined as intermittent or permanent gonadal insufficiency before age of 40 years. POI causes female infertility hence pregnancies are uncommon but not impossible. Ovarian failure is not permanent, unlike menopause. There could be intermittent ovulation and spontaneous pregnancy. Many protocols aimed to restore ovarian functions have been described in the recent years. This is a case of POI women who conceived spontaneously in the immediate menstrual cycle after a failed attempt at ovarian stimulation following many years on hormone replacement therapy (HRT). She had an unremarkable pregnancy and delivered a healthy baby via caesarean section.


Keywords


Premature ovarian failure, Premature ovarian insufficiency, Gonadal insufficiency, Ovulation induction, Hypergonadotrophic hypogonadism

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References


Panay N, Anderson RA, Nappi RE, Vincent AJ, Vujovic S, Webber L, et al. Premature ovarian insufficiency: an International Menopause Society White Paper, Climacteric. 2020;23(5):426-46.

Coulam CB, Adamson SC, Annegers JF. Incidence of premature ovarian failure. Obstet Gynecol. 1986;67:604-6.

European Society for Human Reproduction and Embryology (ESHRE) Guideline Group on POI; Webber L, Davies M, Anderson R, Bartlett J, Braat D, et al. ESHRE guideline: management of women with premature ovarian insufficiency. Hum Reprod. 2016;31:926-37.

De Vos M, Devroey P, Fauser BC. Primary ovarian insufficiency. Lancet. 2010;376:911-21.

Nelson LM. Clinical practice: primary ovarian insufficiency. N Engl J Med. 2009;360:606-14

Bidet M, Bachelot A, Bissauge E. Resumption of ovarian function and pregnancies in 358 patients with premature ovarian failure. J Clinical Endocrinol Metab. 2011;96:3864-72.

Oyesanya OA, Olufowobi O, Ross W, Sharif K, Afnan M. Prognosis of oocyte donation cycles: a prospective comparison of the in vitro fertilization-embryo transfer cycles of recipients who used shared oocytes versus those who used altruistic donors. Fertil Steril. 2009;92:930-6.

Paulson RJ, Hatch IE, Lobo RA, Sauer MV. Cumulative conception and live birth rates after oocyte donation: implications regarding endometrial receptivity. Hum Reprod. 1997;12(4):835-9.

Gu Y, Xu Y. Successful Spontaneous Pregnancy and Live Birth in a Woman With Premature Ovarian Insufficiency and 10 Years of Amenorrhea: A Case Report. Front Med. 2020;7:18.

Dragojević Dikić S, Rakić S, Nikolić B, Popovac S. Hormone replacement therapy and succesful pregnancy in a patient with premature ovarian failure. Gynecol Endocrinol. 2009;25:769-72.

Tartagni M, Cicinelli E, De Pergola G. Effect of pretreatment with estrogens on ovarian stimulation with gonadotropins in women with premature ovarian failure: a randomized, placebo controlled trial. Fertil Steril. 2007;87:858-61.

Ben-Nagi J, Panay N. Premature ovarian insufficiency: how to improve reproductive outcome? Climacteric. 2014;17:242-6.

Badawi A, Goda H, Ragab A. Induction of Ovulation in idiopathic premature ovarian failure: a randomised double-blind trial. Reprod Bio Med Online. 2007;15(2):215-9.