Effect of maternal dexamethasone administration on daily fetal movement count and its correlation with Doppler studies and cardiotocography

Authors

  • Mohamed A. Ali Department of Oobstetrics and Gynecology, Faculty of medicine, Ain Shams University, Cairo, Egypt http://orcid.org/0000-0002-2917-9628
  • Hassan A. Bayoumy Department of Oobstetrics and Gynecology, Faculty of medicine, Ain Shams University, Cairo, Egypt
  • Ahmed S. Elshabrawy Department of Obstetrics and Gynecology, Ahrar Teaching Hospital, Cairo, Egypt

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20212352

Keywords:

Dexamethasone, Fetal movement count, Doppler studies, Cardiotocography, Preterm birth

Abstract

Background: Decreased fetal movements is a frequent reason for unplanned consultations through the third trimester ranging between 4% and 16% in various populations it is often a sign of fetal compromise and associated with severe outcomes such as fetal growth restriction, preterm birth and fetal death therefore it is important to question the effect of maternal dexamethasone administration for fetal well-being and its relation on decreased fetal movement which is detected by Doppler studies and cardiotocography.

Methods: The current study was performed on 220 pregnant women with gestational age between 28-34 weeks who received antenatal dexamethasone at Ain Shams university hospitals.

Results: Regarding fetal movements, there was significant decrease in fetal movement at the 24th hour (Day 2) after 1st and 2nd doses of dexamethasone then re-increased at 48th hour and 72nd hour but still significantly lower than baseline.

Conclusions: Administration of dexamethasone had no harmful effects on the fetuses or the mothers, except for a transient decrease of fetal movements in only after 24 hours of the first dose.

 

Author Biographies

Mohamed A. Ali, Department of Oobstetrics and Gynecology, Faculty of medicine, Ain Shams University, Cairo, Egypt

Lecturer at the Department of Obstetrics and Gynecology, Faculty of medicine, Ain Shams University, Cairo, Egypt

Hassan A. Bayoumy, Department of Oobstetrics and Gynecology, Faculty of medicine, Ain Shams University, Cairo, Egypt

Professor at the Department of Obstetrics and Gynecology, Faculty of medicine, Ain Shams University, Cairo, Egypt

Ahmed S. Elshabrawy, Department of Obstetrics and Gynecology, Ahrar Teaching Hospital, Cairo, Egypt

Resident of Obstetrics and Gynecology, Ahrar Teaching Hospital,Cairo, Egypt. Postal address: 12563

References

Michael GR. What is preterm labor? Medscape. 2021;260998.

Liggins G, Howie R. Fetal lung maturity. J Obstetr Gynecol India. 2005;55(1):3.

Joshi S, Kotecha S. Lung growth and development. Early Hum Dev. 2007;83:789-94.

Tveit JV, Saastad E, Stray-Pedersen B, Børdahl PE, Flenady V, Fretts R et al. Reduction of late stillbirth with the introduction of fetal movement information and guidelines–a clinical quality improvement. BMC pregnancy childbirth. 2009;9(1):1-0.

Scifres CM, Macones GA. Antenatal Testing-Benefits and Costs. Seminars Perinatol. 2008;32(4):318-21.

Bozkurt N, Yiğiter BA, Gokaslan H, Kavak ZN. Correlations of fetal-maternal outcomes and first trimester 3-D placental volume/3-D power Doppler calculations. Clin Exp Obstet Gynecol. 2010;37(1):26-8.

Gravett MG, Eckert LO, Michael G, Dudley DJ, Stringer EM, Mujobu TB et al. Non-reassuring fetal status: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine. 2016;34(49):6084-92.

World Health Organization. Recommendation on daily fetal movement counting. 2008. Available at: https://apps.who.int/iris/bitstream/handle/10665/250796/9789241549912-eng.pdf;jsessionid=4D54BFAC C7671FC6FF6F1C932F5E6DE8?sequence=1. Accessed on 3 March 2021.

Umana OD, Siccardi MA. Prenatal Non-Stress Test. StatPearls 2020. Available from: https://www.ncbi. nlm.nih.gov/books/NBK537123/. Accessed on 01 January 2020.

Saigal S, Doyle LW. An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet. 2007;371(9608):261-9.

Wahby Y, Raslan A, El Ghazaly H, El Kateb A. 'Effects of Maternal Dexamethasone Administration on Daily Foetal Movement Count and its Correlation with Doppler Studies and Non-Stress Test. Evidence Based Women's Health J. 2017;7(1):15-21.

Saccone G, Berghella V. Antenatal corticosteroids for maturity of term or near-term fetuses: systematic review and meta-analysis of randomized controlled trials. Bio Med J. 2016;12;355.

Senat MV, Ville Y. Effect of steroids on arterial Doppler in intrauterine growth retardation fetuses. Fetal Diagn Ther. 2000;15(1):36-40.

Chitrit Y, Caubel P, Herrero R, Schwinte AL, Guillaumin D, Boulanger MC. Effects of maternal dexamethasone administration on fetal Doppler flow velocity waveforms. BJOG. 2000;107(4):501-7.

Urban R, Lemancewicz A, Przepieść J, Urban J, Kretowska M. Antenatal corticosteroid therapy: A comparative study of dexamethasone and betamethasone effects on fetal Doppler flow velocity waveforms. Eur J Obstet Gynecol Reprod Biol. 2005;120(2):170-4.

Mushkat Y, Ascher-Landsberg J, Keidar R, Carmon E, Pauzner D, David MP. The effect of betamethasone versus dexamethasone on fetal biophysical parameters. Eur J Obstet Gynecol Reprod Biol. 2001;97(1):50-52.

Multon O, Senat MV, Minoui S, Hue MV, Frydman R, Ville Y. Effect of antenatal betamethasone and dexamethasone administration on fetal heart rate variability in growth-retarded fetuses. Fetal Diagn Ther. 2017;12(3):170-7.

Dawes GS, Serra-Serra V, Moulden M, Redman CW. Dexamethasone and fetal heart rate variation. Br J Obstet Gynaecol. 2010;101(8):675-9.

Rotmensch S, Lev S, Kovo M, Efrat Z, Zahavi Z, Lev N et al. Effect of betamethasone administration on fetal heart rate tracing: A blinded longitudinal study. Fetal Diagn Ther. 2015;20(5):371-6.

Derks JB, Mulder EJ, Visser GH. The effects of maternal betamethasone administration on the fetus. Br J Obstet Gynaecol. 2011;102(1):40-6.

Magee LA, Dawes GS, Moulden M, Redman CW. A randomised controlled comparison of betamethasone with dexamethasone: Effects on the antenatal fetal heart rate. Br J Obstet Gynaecol. 2013;104(11):1233-8.

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Published

2021-06-28

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Original Research Articles