DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20212171

A study of various neonatal outcomes and complications in live-born infants among IVF pregnancies

Chetan Yadav, Charu Yadav

Abstract


Background: In-vitro fertilization or Assisted reproductive techniques (ART) is the most advanced technique of infertility treatment. In-vitro fertilization (IVF) has helped couples all over the world. However, the use of IVF has raised significant concern about the outcome of resulting pregnancies and the health of the newborns. There is a range of possible factors associated with the treatment that may contribute to potential adverse outcomes. Thus, the study was conducted to analyze the neonatal outcomes of children born by ART in the Indian context.

Methods: The neonatal characteristics and complications of the live-born infants through IVF at Army Hospital R and R were analyzed in this study between March 2019 to February 2020.

Results: Total 231 babies were born to the study group cases. 126 (54.54%) were singletons, 102 (44.16%) were of twin pregnancies and 1.3% were triplets. There were 65.36% term and 34.63% preterm. Of the 231 IVF neonates, 58 needed neonatal intensive care. There were 219 (94.8%) survivors, while 12 (5.2%) did not survive a week. The 16 (6.92%) survivors needed readmissions mainly due to hyperbilirubinemia. There were 106 (45.8%) babies whose weight was less than 2 kg.

Conclusions: Infertility cases are usually older, and this is one reason for increased pregnancy and newborn infant complications. Neonates born through IVF appeared to be at higher risk of multiple births, prematurity, low birth weight, and other disabilities.


Keywords


Infertility, In-vitro fertilization, Low-birth weight, Neonates

Full Text:

PDF

References


Aboulghar MA. Perinatal Complications of Assisted Reproduction. Croat Med J. 2005;46(5):751-8.

Friedler S, Mashiach S, Laufer N. Births in Israel resulting from in-vitro fertilization/embryo transfer, 1982–1989: National Registry of the Israeli Association for Fertility Research. Hum Reprod. 1992;7:1159-63.

Balen AH, MacDougall J, Tan SL. The influence of the number of embryos transferred in 1060 in-vitro fertilization pregnancies on miscarriage rates and pregnancy outcome. Hum Reprod. 1993;8:1324-8.

Gissler M, Malin Silverio M, Hemminki, E. In-vitro fertilization pregnancies and perinatal health in Finland 1991–1993. Hum Reprod. 1995;10:1856-61.

Bergh T, Ericson A, Hillensjö T, Nygren KG, Wennerholm UB. Deliveries and children born after in-vitro fertilization in Sweden 1982–95: a retrospective cohort study. Lancet. 1999;354:1579-85.

Buitendijk SE. Children after in vitro fertilization. An overview of the literature. Int. J. Technol. Assess. Health Care. 1999;15:52-65.

D’Souza SW, Rivlin E, Cadman J, Richards B, Buck P, Lieberman BA. Children conceived by in vitro fertilisation after fresh embryo transfer. Arch Dis Child Fetal Neonatal Ed. 1997;76:70-4.

Addor V, Santos-Eggiman B, Fawer CL, Paccaud F, Calame A. Impact of infertility treatments on the health of newborns. Fertil Steril. 1998;69:210-5.

Koudstaal J, Braat DDM, Bruinse HW, Naaktgeboren N, Vermeiden JPW, Visser GHA. Obstetric outcome of singleton pregnancies after IVF: a matched control study in four Dutch university hospitals. Hum Reprod. 2000;15:1819-25.

Lancaster PAL. Congenital malformations after in-vitro fertilization. Lancet. 1987;2:1392-3.

Ericson A, Källén B. Congenital malformations in infants born after IVF: a population-based study. Hum Reprod. 2001;16:504-9.

Westergaard HB, Tranberg-Johansen AM, Erb K, Anderson AN. Danish National In-Vitro Fertilisation Registry 1994 and 1995: A controlled study of births, malformations and cytogenetic findings. Hum Reprod. 1999;14:1896-902.

Rizk B, Doyle P, Tan SL, Rainsbury P, Betts J, Brinsden P, et al. Perinatal outcome and congenital malformations in in-vitro fertilisation babies from the Bourn-Hallam group. Hum Reprod. 1991;6:1259-64.

Reynolds MA, Schieve LA, Martin JA, Jeng G, Macaluso M. Trends in multiple births conceived using assisted reproductive technology, United States, 1997-2000. Paediatrics. 2003;111:1159-62.

Koivurova S, Hartikainen AL, Sovio U, Gissler M, Hemminki E, Jarvelin MR. Growth, psychomotor development and morbidity up to three years of age in children born after IVF. Hum Reprod .2003;18:2328-36.

Reefhuis J, Honein MA, Schieve LA, Correa A, Hobbs CA, Rasmussen SA. National Birth Defects Prevention Study. Assisted reproductive technology and major structural birth defects in the United States. Hum Reprod. 2009;24(2):360-6.

Poikkeus P, Gissler M, Unkila-Kallio L, Hyden-Granskog C, Tiitinen A. Obstetric and neonatal outcome after single embryo transfer. Hum Reprod. 2007;22:1073-9.

Hansen M, Colvin L, Petterson B, Kruinczuk JJ, de Klerk N, Bower C. Admission to hospital of singleton children following assisted reproductive technology (ART). Hum Reprod. 2008;23:1297-305.

Engmann L, Maconochie N, Lin Tan S, Bekir J. Trends in the incidence of births and multiple births and the factors that determine the probability of multiple births after IVF treatment. Hum Reprod. 2001;16:2598-605.

Stromberg B, Dahlquist G, Ericson A, Finnstr€om O, K€oster M, Stjenquist K. Neurological sequelae in children born after in-vitro fertilization: a population- based study. Lancet. 2002;359:461-5.