Safety of pregnancy in uterine fibroids

Authors

  • Maha Alhainiah College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
  • Elaf Aljifry College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
  • Ayman Alghamdi College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
  • Lujain Alrabghi College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
  • Abdullah Alharbi College of Medicine, Ibn Sina National College, Jeddah, Saudi Arabia
  • Ezdehar Alrowaithi College of Medicine, Ibn Sina National College, Jeddah, Saudi Arabia
  • Fatimah Almuallem College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
  • Elaf Fakeih College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
  • Bassmah Alrowaithi Department of Obstetrics and Gynaecology, East Jeddah Hospital, Jeddah, Saudi Arabia
  • Hassan Allam Department of Obstetrics and Gynecology, Faculty of Medicine, King Abdulaziz University, Rabigh, Saudi Arabia

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20182924

Keywords:

Complications, Effect, Fibroid, Pregnancy, Safety, Uterine fibroid

Abstract

Uterine fibroid is one of the most common intrauterine masses among females at the reproductive age. Pregnancy and uterine fibroids are highly correlated. Pregnancy-related hormones influence the size of uterine fibroids, and fibroids have many impacts on pregnancy. Although most if the uterine fibroids are asymptomatic during pregnancy, serious complications may occur. The main complications include abortion, premature rupture of membranes, premature labor, abruptio placentae, peripartum hemorrhage, fetal malpresentation, fetal intrauterine growth retardation, small for gestational age infants, and fetal anomalies. The main risk factors for complications are related to the fibroid number, size, volume, location, and type. Large, multiple, retroplacental, submucosal, subserosal, pedunculated, or low-lying fibroids carries the highest risk for complications during pregnancy. This review will address the prevalence of uterine fibroids during pregnancy, its effects, and complications.

References

Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM. High cumulative incidence of uterine leiomyoma in black and white women: Ultrasound evidence. Am J Obstet Gynecol. 2003;188(1):100-7.

Johnson NL, Norwitz E, Segars JH. Management of Fibroids in Pregnancy. In: Fibroids. 2013:36-53.

Parker WH. Etiology, symptomatology, and diagnosis of uterine myomas. Fertil Steril. 2007;87(4):725-36.

Nair S. Contemporary Management of Fibroids. Ann Acad Med Singapore. 2003;32(5):615-23.

Shavell VI, Thakur M, Sawant A, Kruger ML, Jones TB, Singh M, Puscheck EE, Diamond MP. Adverse obstetric outcomes associated with sonographically identified large uterine fibroids. Fertil Steril. 2012;97(1):107-10.

Cooper NP, Okolo S. Fibroids in pregnancy-common but poorly understood. Obstet Gynecol Surv. 2005;60(2):132-8.

Evans P, Brunsell S. Uterine fibroid tumors: Diagnosis and treatment. Am Fam Physician. 2007;75(10):1503-8.

Calaf J, Arque M, Porta O, D’Angelo E. (The fibroid as clinical problem). Med Clin (Barc). 2013;141 Suppl:1-6.

Vitale SG, Tropea A, Rossetti D, Carnelli M, Cianci A. Management of uterine leiomyomas in pregnancy: Review of literature. Updates Surg. 2013;65(3):179-82.

Donnez J, Dolmans MM. Uterine fibroid management: From the present to the future. Hum Reprod Update. 2016;22(6):665-86.

Myers SL, Baird DD, Olshan AF, Herring AH, Schroeder JC, Nylander-French LA, Hartmann KE. Self-report versus ultrasound measurement of uterine fibroid status. J Women's Health. 2012;21(3):285-93.

Lev-Toaff S, Coleman BG, Arger PH, Mintz MC, Arenson RL, Toaff ME. Leiomyomas in pregnancy: sonographic study. Radiology. 1987;164(2):375-80.

Benaglia L, Cardellicchio L, Filippi F, Paffoni A, Vercellini P, Somigliana E, Fedele L, et al. The rapid growth of fibroids during early pregnancy. PloS one. 2014;9(1):e85933.

Rosati P, Exacoustos C, Mancuso S. Longitudinal evaluation of uterine myoma growth during pregnancy: A sonographic study. J Ultrasound Med. 1992;11(10):511-5.

Neiger R, Sonek JD, Croom CS, Ventolini G. Pregnancy-related changes in the size of uterine leiomyomas. J Reprod Med. 2006;51:671-4.

De Vivo A, Mancuso A, Giacobbe A, et al. Uterine myomas during pregnancy: A longitudinal sonographic study. Ultrasound Obstet Gynecol. 2011;37(3):361-5.

Shikawa H, Ishi K, Ann Serna V, Kakazu R, Bulun SE, Kurita T. Progesterone is essential for maintenance and growth of uterine leiomyoma. Endocrinology. 2010;151(6):2433-42.

Hammoud AO, Asaad R, Berman J, Treadwell MC, Blackwell S, Diamond MP. Volume change of uterine myomas during pregnancy: Do myomas really grow? J Minim Invasive Gynecol. 2006;13(5):386-90.

Horiuchi A, Nikaido T, Yoshizawa T, et al. HCG promotes proliferation of uterine leiomyomal cells more strongly than that of myometrial smooth muscle cells in vitro. Mol Hum Reprod. 2000;6(6):523-8.

Aharoni A, Reiter A, Golan D, Paltiely Y, Sharf M. Patterns of growth of uterine leiomyomas during pregnancy. A prospective longitudinal study. Br J Obstet Gynaecol. 1988;95(5):510-3.

Akinyemi BO, Adewoye BR, Fakoya TA. Uterine fibroid: a review. Niger J Med. 2004;13(4):318-29.

Klatsky PC, Tran ND, Caughey AB, Fujimoto VY. Fibroids and reproductive outcomes: a systematic literature review from conception to delivery. Am J Obstet Gynecol. 2008;198(4):357-66.

Zaima A, Ash A. Fibroid in pregnancy: Characteristics, complications, and management. Postgrad Med J. 2011;87(1034):819-28.

Winer-Muram HT, Muram D, Gillieson MS, Ivey BJ, Muggah HF. Uterine myomas in pregnancy. Can Med Assoc J. 1983;128(8):949-50.

Xacoustos C, Rosati P. Ultrasound diagnosis of uterine myomas and complications in pregnancy. Obs Gynecol. 1993;82:97-101.

Navid S, Arshad S, Qurat-ul-Ain, Meo RA. Impact of leiomyoma in pregnancy. J Ayub Med Coll Abbottabad. 2012;24(1):90-2.

Sparić R. Uterine myomas in pregnancy, childbirth and puerperium. Srp Arh Celok Lek. 2014;142(1-2):118-24.

Hasan F, Arumugam K, Sivanesaratnam V. Uterine leiomyomata in pregnancy. Int J Gynecol Obstet. 1991;34(1):45-8.

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Published

2018-07-26

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Review Articles