Effect of hormone replacement therapy on biochemical parameters in post-menopausal women

Authors

  • Jayaprada Thigula Department of Obstetrics and Gynecology, Maheshwara Medical College and Hospital, Isnapur, Patancheru, Hyderabad, Telangana, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20174454

Keywords:

Menopause, Hormone replacement therapy (HRT), Lipoproteins, Lipid profile

Abstract

Background: In females, menopause is a loss of natural events that marks the end of the reproductive years. Menopause its associated complications can be managed by hormone replacement therapy (HRT). This study hypothesized to evaluate the effect of hormone replacement therapy on clinico biochemical levels in postmenopausal women.

Methods: A total one hundred postmenopausal females were considered. Based on medication administered patients were divided in to five groups i.e. Premarin group, Ovral-L group, Evalon group, Transdermal E2 Gel group and Control group with oral calcium placebo therapy. A complete Haemogram, ECG, Urine examination, lipid profile were investigated.

Results: Most common clinical symptoms is vasomotor/psychological (45% in all groups) related followed by urogenital/psychological symptoms (22% in all groups). The mean lipid lipoproteins before therapy, after 2 months and 6 months follow up showed significant change in all the groups.

Conclusions: HRT can be a safe method to manage urogenital complication and vasomotor symptoms in postmenopausal women. It has a notable impact on the lipid profile and lipoproteins which helps to reduce the chances to get associated health complications.

References

Maninder Ahuja. Age of menopause and determinants of menopause age: A PAN India survey by IMS. J Midlife Health. 2016;7(3):126–31.

Lee KS, Roh JS, Kim JG, Kim SH, Choi YM, Shin CJ, et al. The effect of ipriflavone on serum lipid profiles in postmenopausal women. J Korean Soc Menopause. 1996;2:27-35.

Heo J, Park Y, Park HM. Dietary intake of nutrients and food in postmenopausal Korean women. J Korean Soc Menopause. 2011;17:12-20.

Kwon OS, Kim JH, Cho SH, Park HM, Sung EJ. The association between subclinical hypothyroidism and cardiovascular risk factors in post-menopausal women. J Korean Soc Menopause. 2012;18:193-8.

Lee SR, Cho SB, Jeong KA. Serum lipid profiles and thyroid function tests in elderly women. J Korean Soc Menopause. 2009;15:186-92.

Soma MR, Osnago-Gadda I, Paoletti R, Fumagalli R, Morrisett JD, Meschia M, et al. The lowering oflipoprotein[a] induced by estrogen plus progesterone replacement therapy in postmenopausal women. Arch Intern Med. 1993;153:1462-8.

Crook D, Stevenson JC. Transdermal hormone replacement therapy, serum lipids and lipoproteins. Br J Clin Pract Suppl. 1996;86:17-21.

Jensen J, Riis BJ, Strøm V, Nilas L, Christiansen C. Long-term effects of percutaneous estrogens and oral progesterone on serum lipoproteins in postmenopausal women. Am J Obstet Gynecol. 1987;156:66-71.

Meschia M, Bruschi F, Soma M, Amicarelli F, Paoletti R, Crosignani P. Effects of oral and transdermal hormone replacement therapy on lipoprotein(A) and lipids: a randomized controlled trial. Menopause. 1998;5:157-62.

Chen FP, Lee N, Wang Ch H, Cherng WJ, Soong YK. Effects of hormone replacement therapy on cardiovascular risk factors in Postmenopausal women. Fertil Steril. 1998;69(2):267-73.

Nabulsi AA, Folsom AR, White A, Patsch W, Heiss G, Wu KK, et al. Association of hormone replacement therapy with various cardiovascular risk factors in postmenopausal women. N Eng J Med. 1993;328:1069-75.

Speroff L. Postmenopausal hormone therapy and coronary heart disease: clinical implications of recent randomised trial results. Maturitas. 2000;35:91-7.

Mosekilde L, Beck-Nielson H, Sørensen OH, Nielsen SP, Charles P, Vestergaard P, et al. Hormone replacement therapy reduces forearm fracture incidence in recent postmenopausal women – results of the Danish Osteoporosis prevention Study. Maturitas. 2000;36(3):181-93.

Brincat MP. Hormone replacement therapy and the skin. Maturitas. 2000;35:107-17.

Paganini-Hill A, Henderson VW. Oestrogen replacement therapy & risk of Alzheimer’s disease. Arch Intern Med. 1996;156:2213-17.

Larry WB. Sex steroids & Alzheimer’s disease. J Gerontol. 2005;60A:736–43.

Arora S, Jain A, Chitra R. Effects of short-term hormone replacement on atherogenic indices in indian postmenopausal women. Indian J Clin Biochem. 2006;21(1):41-7.

Aitken JM, Lorimer AR, Hart DM, Lawrie TDV, Smith DA. The effects of oophorectomy and long term mestranol therapy on serum lipids on middle age women. Clin Sci. 1971;41:597-603.

Oya, Gokman, Elif G, Yapar, Eyi. Hormone Replacement Therapy and lipid - lipoprotein concentrations. Eur J Obstet Gynecol Reprod Biol. 1999;85:31-41.

Godsland IF. Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein and apolopoprotein (a) concentrations analysis of studies published from 1974-2000. Fertil Steril. 2001;75:898-915.

Downloads

Published

2017-09-23

Issue

Section

Original Research Articles