The effects of combined therapy of myo-inositol and D-chiro inositol in reduction of the individual components of metabolic syndrome in overweight PCOS patients compared to myo-inositol supplementation alone: a prospective randomised controlled trial

Authors

  • Manideepa Pande Department of Obstetrics and Gynecology, Vivekananda Institute of Medical Sciences, Kolkata, West Bengal, India
  • Ashish Seal Department of Obstetrics and Gynecology, Vivekananda Institute of Medical Sciences, Kolkata, West Bengal, India
  • Sukanta Mishra Department of Obstetrics and Gynecology, Vivekananda Institute of Medical Sciences, Kolkata, West Bengal, India
  • Arup Dasgupta Department of Anaesthesiology, ICARE Institute of Medical Sciences and Research, Banbishnupur, Purba Medinipur, Haldia, West Bengal, India
  • Mousumi Sengupta Department of Radiology, Vivekananda Institute of Medical Sciences, Kolkata, West Bengal, India
  • Rinini Dastider Department of Biochemistry, Vivekananda Institute of Medical Sciences, Kolkata, West Bengal 700026, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20172911

Keywords:

Anovulation, D-chiro-inositol, Hirsutism, Myo-inositol, PCOS

Abstract

Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorder affecting five to ten percent women of reproductive age group. Variability of signs and symptoms along with metabolic syndrome as one of the long term complications make it worthy of early diagnosis and treatment. Medical management of PCOS is aimed at the treatment of metabolic derangements, anovulation, hirsutism, and menstrual irregularities.

Methods: 140 patients, using inclusion and exclusion criteria, were selected and randomly divided into two groups (seventy in each) and age, BMI, waist hip ratio, blood pressure (systolic, diastolic), serum fasting insulin, fasting blood sugar, total cholesterol, HDL, LDL, triglycerides were measured. Study group were given {Myo-inositol (550 mg) + D-chiro-inositol (13.8 mg)} (MI+DCI) twice daily and the control group were given Myo-inositol (1 gm) (MI) twice daily for six months. Same variables were measured at the end of three and six months and compared with repeated measurement ANOVA using SPSS (version 20).

Results: Comparison between these two groups before study was non-contributory. Combined drug therapy has provided statistically significant decrease in BMI, W:H ratio, Diastolic BP, Fasting blood sugar at the end of both 3rd and 6th month but in case of LDL it was at the end of 3 months. Combined drug therapy also increased the HDL level significantly in both the occasions.

Conclusions: Combined medical therapy by (MI+DCI) is very much helpful in reducing the metabolic complications of PCOS without any major side effects.

References

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Published

2017-06-24

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Original Research Articles